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Enable Innovative Drug Discover with DEL, FBDD and SBDD

  1. About
  2. Publications

Publications

  • 19 April 2024
    The discovery of novel and potent indazole NLRP3 inhibitors enabled by DNA-encoded library screening
    Bioorganic & Medicinal Chemistry Letters 10.1016/j.bmcl.2024.129675
  • 26 April 2023
    Carbohydrate?DNA Conjugation Enabled by Glycosyl Radicals Generated from Glycosyl Sulfinates
    Org Lett. 10.1021/acs.orglett.3c00833
  • 14 March 2023
    Expanding the DNA-encoded library toolbox: identifying small molecules targeting RNA
    Nucleic Acids Res. https://doi.org/10.1093/nar/gkac173
  • 06 January 2023
    Optimization of PROTAC Ternary Complex Using DNA Encoded Library Approach
    ACS Chem Biol. 10.1021/acschembio.2c00797
  • 26 August 2022
    PAC-FragmentDEL – photoactivated covalent capture of DNA-encoded fragments for hit discovery
    RSC Med. Chem. 10.1039/d2md00197g
  • 11 April 2022
    Palladium-Mediated Hydroamination of DNA-Conjugated Aryl Alkenes
    Frontiers in Chemistry 10.3389/fchem.2022.851674
  • 01 April 2022
    Photoredox Deaminative Alkylation in DNA-Encoded Library Synthesis
    Organic Letters 2022 24 (14), 2650-2654 DOI: 10.1021/acs.orglett.2c00697
  • 24 August 2021
    A Novel Scalarized Scaffold Hopping Algorithm with Graph-Based Variational Autoencoder for Discovery of JAK1 Inhibitors
    ACS Omega:A Novel Scalarized Scaffold Hopping Algorithm with Graph-Based Variational Autoencoder for https://doi.org/10.1021/acsomega.1c03613
  • 04 August 2021
    On-DNA Derivatization of Quinoxalin-2-ones by Visible-Light-Triggered Alkylation with Carboxylic Acids
    Bioconjug Chem:On-DNA Derivatization of Quinoxalin-2-ones by Visible-Light-Triggered Alkylation with https://doi.org/10.1021/acs.bioconjchem.1c00346
  • 11 May 2021
    Toward the assembly and characterization of an encoded library hit confirmation platform: Bead-Assisted Ligand Isolation Mass Spectrometry (BALI-MS)
    Bioorg. Med. Chem. 41 (2021) 116205 https://10.1016/j.bmc.2021.116205

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