Welcome to HitGen
CN EN

Capabilities

One-stop Technology Platform to Accelerate Drug Discovery and Development

Capabilities

DMPK

Drug metabolism and pharmacokinetics (DMPK) study investigate the absorption, distribution, metabolism and excretion (ADME) character of drug with a variety of technologies, which provide data for optimization of drug to acquire desirable in vivo performance, as well as predicting the ADME of drug when dosing to human.


In vitro/in vivo DMPK tools are throughout used in drug development. Based on DNA encoded library-directed drug development, HitGen has built a fast, economic and high-throughput DMPK study platform to support different stages of drug development from hit screening, lead optimization towards PCC confirmation.


In vitro DMPK 

  • Microsomal stability for multiple species (H, Ms, R, D, MK)

  • Hepatocyte stability for multiple species (Ms, R, D, MK)

  • Microsome/Hepatocyte-based metabolite identification/GSH adduction

  • Plasma protein binding

  • Cell uptake and efflux

  • CYP450 inhibition assay

  • PAMPA-based permeability assay


In vivo DMPK 

  • General pharmacokinetics

  • Cassette PK screening for multiple compounds

  • In vivo metabolites identification 

  • Tissue distribution


Thanks for reading!

For more details on how we can advance your innovative drug discovery projects
验证码
By submitting your information, you acknowledge having received, read and understood our Privacy Notice as made available above.

We use cookies to provide a better web experience.
By using our site, you acknowledge our use of cookies and please read our Cookie Notice for More information

XML 地图 | Sitemap 地图

欧洲杯竞猜官方平台