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Hit Expansion by DEL

Medicinal chemistry projects began adapting and using DNA-encoded library technology not only for the hit-discovery process to produce high-quality hits, but also for the lead optimization process. DELs can rapidly expand millions to billions of member around a hit or lead compound to improve potency, selectivity or other drug-like properties. 


  • To obtain best fragment combination and cover broader chemical space.

  • Focused DELs are designed and synthesized for specific target selection to optimize hit compounds in a timely manner.

  • Focused DELs may provide richer SAR information to guide MedChem optimization.

  • The focused DELs can also be used for other homologous target screening

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