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Enabling Innovative Drug Discovery with Advanced Technologies

  1. Services
  2. Lead Optimization

Lead Optimization

Lead optimization stage of drug discovery is to maintain favorable properties in lead compounds while improving on deficiencies in the lead structure. The goal of lead optimization is to generate one or several preclinical candidates. Generally molecules need to be examined in efficacy and toxicity, PK/PD studies, metabolic profiling, chemical stability study, salt selection. HitGen provide services in medicinal chemistry, computational chemistry, AI based designproject DEL, compound scale-up, in vitro toxicity, in vitro pharmacology, in vivo pharmacology, pharmacokinetics, non-GLP toxicity.

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